pI: 6.279 |
Length (AA): 127 |
MW (Da): 13796 |
Paralog Number:
13
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127421)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_41850 | Associated with TFs and helicases family protein |
Caenorhabditis elegans | CELE_T04D1.4 | Protein CHD-7 |
Cryptosporidium hominis | Chro.40182 | RIKEN cDNA A730019I05 gene |
Cryptosporidium parvum | cgd4_1590 | chromodomain-helicase-DNA-bindingmultidomain chromatin protein with the following architecture: chromo-bromo-chromo-SNF2 ATpase |
Dictyostelium discoideum | DDB_G0280705 | CHR group protein |
Drosophila melanogaster | Dmel_CG3696 | kismet |
Echinococcus granulosus | EgrG_000564800 | BRK domain containing protein |
Echinococcus granulosus | EgrG_000512800 | Chromo domain |
Entamoeba histolytica | EHI_115350 | chromodomain-helicase-DNA-binding protein, putative |
Entamoeba histolytica | EHI_000780 | chromodomain-helicase-DNA-binding protein, putative |
Echinococcus multilocularis | EmuJ_000299500 | |
Echinococcus multilocularis | EmuJ_000515400 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000565900 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000567000 | BRK domain containing protein |
Echinococcus multilocularis | EmuJ_000270800 | BRK domain containing protein |
Echinococcus multilocularis | EmuJ_000402200 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000564400 | BRK domain containing protein |
Echinococcus multilocularis | EmuJ_000271000 | chromodomain helicase DNA binding protein 7 |
Echinococcus multilocularis | EmuJ_000022400 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000563800 | BRK domain containing protein |
Echinococcus multilocularis | EmuJ_000512800 | Chromo domain |
Echinococcus multilocularis | EmuJ_000299900 | |
Echinococcus multilocularis | EmuJ_000564800 | BRK domain containing protein |
Echinococcus multilocularis | EmuJ_000026800 | BRK domain containing protein |
Homo sapiens | ENSG00000100888 | chromodomain helicase DNA binding protein 8 |
Homo sapiens | ENSG00000177200 | chromodomain helicase DNA binding protein 9 |
Homo sapiens | ENSG00000171316 | chromodomain helicase DNA binding protein 7 |
Homo sapiens | ENSG00000124177 | chromodomain helicase DNA binding protein 6 |
Loa Loa (eye worm) | LOAG_02125 | helicase |
Loa Loa (eye worm) | LOAG_09381 | helicase DNA-binding protein |
Mus musculus | ENSMUSG00000053754 | chromodomain helicase DNA binding protein 8 |
Mus musculus | ENSMUSG00000056608 | chromodomain helicase DNA binding protein 9 |
Mus musculus | 102643201 | chromodomain-helicase-DNA-binding protein 9-like |
Mus musculus | ensembl-mmu:ENSMUSG00000057133 | chromodomain helicase DNA binding protein 6 |
Mus musculus | ENSMUSG00000041235 | chromodomain helicase DNA binding protein 7 |
Schistosoma japonicum | Sjp_0006120 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma mansoni | Smp_130470 | hypothetical protein |
Schmidtea mediterranea | mk4.004621.06 | |
Schmidtea mediterranea | mk4.004621.04 | |
Schmidtea mediterranea | mk4.000079.09 | Chromodomain-helicase-DNA-binding protein 6 |
Trichomonas vaginalis | TVAG_035500 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_264810 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_382210 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_008030 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_302840 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_126300 | chromodomain-helicase-DNA-binding protein, putative |
Trichomonas vaginalis | TVAG_076520 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_368250 | chromodomain-helicase-DNA-binding protein, putative |
Trichomonas vaginalis | TVAG_286450 | chromodomain-helicase-DNA-binding protein, putative |
Trichomonas vaginalis | TVAG_423310 | chromodomain-helicase-DNA-binding protein, putative |
Trichomonas vaginalis | TVAG_308180 | chromodomain-helicase-DNA-binding protein, putative |
Trichomonas vaginalis | TVAG_425870 | chromodomain helicase DNA binding protein, putative |
Trichomonas vaginalis | TVAG_388280 | chromodomain helicase DNA binding protein, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.